Efficacy and Side Effects of Letrozole Over Clomiphene citrate for Ovulation Induction of the Patients with PCOS: A Randomized Controlled Trial
نویسندگان
چکیده
Clomiphene citrate (CC) has been the drug of choice for treatment anovulatory subfertility in women with polycystic ovarian syndrome (PCOS) a long time. Despite high ovulation rate CC, its pregnancy is low. Letrozole, an aromatase inhibitor considered as alternative CC but effectiveness yet controversial. Our aim was to compare efficacy and side effects Letrozole over CC. This randomized control clinical trial conducted Diabetic Association Medical College Hospital, Faridpur, Bangladesh from January 2018 December 2019. A total 160 diagnosed PCOS by Rotterdam criteria seeking were included study. Participants randomly divided into two groups. Group got B treatment. Transvaginal ultrasonogram (TVS) performed on 12 13th day cycle see details follicles endometrium. The demographic information participants drugs recorded. Successful pregnancies followed up weeks. Ovulation almost similar among both But monofo licular development significantly higher group (p = 0.004 p 0.008 respectively). Multifo development, multiple pregnancy, abortion group. Patients who took had endometrial thickness than Both groups reported relatively incidence effects. Due lower or can be effective patients.
 Faridpur Med. Coll. J. 2020;15(2): 69-73
منابع مشابه
Comparison of the Effects of Letrozole and Clomiphene Citrate on Ovulation and Pregnancy Rate in Patients with Polycystic Ovary Syndrome
Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Methods: In this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized int...
متن کاملDoes Adding Dexamethasone to Clomiphene Citrate Improve Ovulation in PCOS Patients? A Triple - Blind Randomized Clinical Trial Study
متن کامل
Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.
OBJECTIVE To compare the effect of letrozole with combined metformin and clomiphene citrate (CC) for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS). DESIGN A randomized controlled trial. SETTING University teaching hospital and a private practice setting. PATIENT(S) Two hundred fifty anovulatory women (582 cycles) with CC-resistant PCOS. INTERVENTION(S) ...
متن کاملA Randomized Clinical Trial on Comparing The Cycle Characteristics of Two Different Initiation Days of Letrozole Treatment in Clomiphene Citrate Resistant PCOS Patients in IUI Cycles
Background There are still many questions about the ideal protocol for letrozole (LTZ) as the commonest aromatase inhibitor (AI) used in ovulation induction. The aim of this study is to compare the ultrasonographic and hormonal characteristics of two different initiation times of LTZ in clomiphene citrate (CC) failure patients and to study androgen dynamics during the cycle. MaterialsAndMethods...
متن کاملInduction of Ovulation with Clomiphene Citrate Versus Clomiphene with Bromocriptine in PCOS Patients with Normal Prolactin: A Comparative Study.
INTRODUCTION Polycystic ovarian syndrome (PCOS) is the main cause of anovulatory infertility. Various combination of drugs have been tried to induce ovulation in PCOS patients with varied result. So, this study was planned to compare the effect of bromocriptine combined with Clomiphene Citrate and Clomiphene Citrate alone, in patients of polycystic ovarian syndrome with normal prolactin level. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Faridpur Medical College Journal
سال: 2021
ISSN: ['2079-3553', '2312-9093']
DOI: https://doi.org/10.3329/fmcj.v15i2.53891